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This hormone, discovered in 1995, seems to regulate food intake. Establishing that fat cells secrete resistin and leptin confirms that these cells are more than metro just "oily stuff in the body," Spiegel says. Fat in the metro body "is an endocrine gland, a hormone-producing substance involved in a dialogue with the brain, liver, and muscle in a complex [process] of metro nutrient metabolism," he says. Leptin doesn't appear to have a straightforward association with diabetes. In rodents, a leptin deficiency causes severe insulin resistance, but people with type II diabetes actually have high concentrations of leptin in their blood. Some research points instead to a compound called tumor necrosis factor alpha as a trigger for insulin resistance, Flier says. Resistin "is almost certainly a piece of the puzzle," Lazar says. "Resistin may actually play a big role in explaining why having too many fat cells can induce insulin resistance." The Pennsylvania researchers have already devised an antibody to resistin, which they used in the mouse tests to inhibit the newfound substance's effects.
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