pp. 994 - 996 big plump intron a

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gold n plump , intron a, acute clinical mastitis, police, nutritional supplement, cherries, plump naked , feedlot f.l, glycerol and fatty acids , queen fat bottomed girls , health, pomegranate, atroshi et, Chua Jr.,  Wendy K. Chung,  X. Sharon Wu-Peng,  Yiying Zhang,  Shun-Mei Liu,  Louis Tartaglia,  Rudolph L. Leibel (1) Mice harboring mutations in the obese (ob) and diabetes (db) genes display similar phenotypes, and it has been proposed that these big plump genes encode the ligand and receptor, respectively, for a physiologic pathway that regulates body weight. The cloning of ob, and the demonstration that it encodes big plump a secreted protein (leptin) that binds specifically to a receptor (OB-R) in the brain, have validated critical aspects big plump of this hypothesis. Here it is shown by genetic mapping and genomic analysis that mouse db, rat fatty (a homolog of db), and the gene encoding the OB-R are the same gene. S. C. Chua Jr., W. K. Chung, X. S. Wu-Peng, Y. Zhang, S.-M. Liu, R. L. Leibel, Laboratory of Human Behavior and Metabolism, Rockefeller University, 1230 York Avenue, Box 181, New York, NY 10021, USA.
pp. 994 - 996 Article Views Abstract Full Text (PDF) Article Tools Manage This intron a Article Submit an E-Letter Add to Personal Folders Download to Citation Manager View PubMed Citation Alert Me When Article intron a is Cited E-mail This Page intron a Request Permission to Use This Article Similar Articles In: Science Magazine PubMed Search Google Scholar for: Articles by Chua, S. C. Articles by Leibel, R. L. Articles citing this article Search PubMed for Articles by: Chua, S. C., Jr. Leibel, R. L. Find Citing Articles in: HighWire Press My Science My Folders My Alerts My Saved Searches Sign In More Information More in Collections Medicine, Diseases Related Jobs from ScienceCareers Medicine Cancer Research/Oncology Clinical Research Science 16 February 1996:Vol. 271. no. 5251, pp. 994 - 996DOI: Prev | Table of Contents | Next Reports Phenotypes of Mouse diabetes and Rat fatty Due to Mutations in the OB (Leptin) Receptor Streamson C.
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