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In this case, 9:6 g of EPA/DHA iv drugs versus placebo led to longer periods of remission and improvement in depressive symptoms in those with bipolar depression.41Some researchers theorize that such high doses of EPA/DHA may not be necessary and iv drugs that low levels of pure EPA may be of benefit.32 In a study published in the American Journal of Psychiatry, researchers showed that just 2g of pure EPA could improve the symptoms of treatment-resistant depression. The researchers found that the EPA (versus placebo), when added to iv drugs an ineffective antidepressant for one month, significantly improved depressive symptoms.42A larger study published in Archives of General Psychiatry replicated these findings, however, this time various doses of EPA were examined. Those on ineffective antidepressants were given 1g, 2g or 4g of pure EPA or a placebo in addition to the medication. Interestingly, the 1g daily dose of EPA led to the most significant improvements over the three-month study; it appeared that less was more.
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