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Finally, omega-3 deficiency also causes a 35 percent reduction in brain phosphatidylserine (PS) levels.26 This is also of relevance when considering that PS has documented research & development antidepressant activity in humans.27,28Mechanisms of EPA/DHA Regulation of MoodDHA is found in high levels in the cells of the central nervous system (neurons); here it acts as a form of scaffolding for structural support.29 When omega-3 intake is inadequate, the nerve cell becomes stiff as cholesterol and omega-6 fatty acids are substituted for omega-3.30 When a nerve cell research & development becomes rigid, proper research & development neurotransmission from cell to cell and within cells will be compromised.31While DHA provides structure and helps to ensure normal neurotransmission, EPA may be more important in the signaling within nerve cells.32
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