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The most elegant and engaging is that leptin resistance (like insulin jeffrey bland resistance) is the result of chronic low-grade inflammation. Because obesity itself produces chronic, low-grade inflammation, leptin resistance can be seen as part of a vicious cycle that contributes to the modern obesity epidemic.INFLAMMATION Inflammation is a component of the body’s response to injury or infection. In pre-modern times, inflammation was recognized by jeffrey bland its classic signs of redness, heat, swelling and pain. With the advent of microscopy in the nineteenth century, it became clear that the macroscopic picture of inflammation is produced by white blood cells that enter inflamed tissues and by dilation of blood vessels that increases blood flow to inflamed areas. During the past fifty years, the microscopic changes of inflammation have been traced to the activity of chemicals produced in the affected tissue.
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