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My interest in the relationship between protein function and physiological adaptation has led me to study the proteins hepaticfatty acid and mechanisms that regulate cardiac contraction. This is a very useful system for such studies for a number of hepaticfatty acid reasons. This first is that as cardiac function is critical to survival and also sensitive to changes in physiological conditions, one would expect selective pressures on contractile proteins to be significant. Second, while the performance and morphology of the vertebrate heart varies considerably across genera, the same complement of proteins is utilized to regulate cardiac contraction. Cloning and sequencing of these proteins from a variety of vertebrate species reveals that their amino acid sequences are highly conserved. Functional differences between the protein isoforms would therefore result from relatively few sequence differences. Third, there has been considerable effort spent to understand the contractile reaction and the proteins involved in human heart models.
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