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These results suggested that either the jeffrey bland phd mastitic cows were more susceptible because of inadequate alpha-Tocopherol status prior to the disease or that the disease caused a depression of alpha-Tocopherol concentrations in plasma and milk. Decreases in alpha-Tocopherol concentrations in blood during other infectious diseases and periods of stress have been reported (Chan et al., 1989). The purpose of the current trial was to determine changes in milk and plasma alpha-Tocopherol concentrations during acute mastitis following jeffrey bland phd intramammary challenge with Escherichia coli. Materials and Methods Experimental Cows. Eighteen cows in the Ohio jeffrey bland phd Agricultural Research and Development Center dairy herd were assigned to six blocks of three. Geometric mean parity was 3.2 (range: 2 to 7) and geometric mean days in milk at challenge was 33 (range 20 to 61 days). Cows were housed in tie-stalls and individually fed a diet containing 1000 IU/day of supplemental alpha-Tocopherol (provided as all-rac--tocopheryl acetate) from parturition through the experimental period.
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