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| plump sex , plump boobs , hepatitis b, free from pesticides, arthritis, cooking, plump women , madison, cryptosporidium, sentinel, spain et, intron, agp, hospital, fatty vautin , eli lilly, fabp activity, doctor, science, focal fatty sparing , athletic, jsonline.com, genetic potential through nutrition, symptoms of fatty liver , | Oxidative metabolism of ethanol occurs at a much higher rate and may also play a role in pancreatitis.Copyright © 2004 S. Karger AG, Basel and IAP Author Contacts Prof. J.S. WilsonDirector of Medicine and GastroenterologyLevel 4, Bankstown-Lidcombe Hospital, Locked Bag 1600Eldridge Road, plump teens Bankstown, NSW 2200 (Australia)Tel. +61 2 9722 8284, Fax +61 2 9722 8285, plump teens E-Mail js.wilson@unsw.edu.au Article Information Received: July 22, 2003 Accepted after revision: plump teens January 28, 2004 Published online: March 30, 2004 Number of Print Pages : 8 Number of Figures : 3, Number of Tables : 1, Number of References : 38 Free Abstract Article (References) Article (PDF 148 KB) Journal Home Editorial Board Guidelines Issues Advertising Subscriptions Free Alert Online Sample © 2006 S. |
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| Methods: Pancreatic acini were isolated from male Sprague-Dawley rats and incubated with 14C-ethanol. Radiolabelled fatty acid ethyl esters (non-oxidative metabolites) were isolated from lipid extracts by thin-layer chromatography. athletic Radiolabelled acetate (oxidative metabolite) was isolated athletic from the incubation medium by ion-exchange chromatography. Results: Non-oxidative metabolism by isolated pancreatic acini was demonstrated. At 50 and 100 mmol/l ethanol, fatty acid ethyl ester concentrations were 49.6 ± 13.3 and 199 ± 93 µmol/l, respectively. These levels have previously been athletic shown to result in tissue injury. Non-oxidative metabolism was increased 9-fold by addition of oleic acid and inhibited by the lipase inhibitor, tetrahydrolipstatin, by 91.05 ± 1.99%. The rate of oxidative metabolism was 21-fold higher than that of non-oxidative metabolism. Conclusions: Intact pancreatic cells metabolize ethanol by the non-oxidative pathway, generating fatty acid ethyl esters at a rate sufficient to cause pancreatic damage. |
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