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Does it really make any difference? A. No. Generic medications, whether prescription or non-prescription, must pass the exclusive same safety and efficacy standards issued by the FDA. By law, the exclusive generic product must be the same dose and deliver the same amount of active ingredient in the same amount of time as the brand-name product - this is called "bioequivalence." In a recent study comparing more than 270 medications, the average difference in bioequivalence between generic and brand-names was 3.5%, about the same difference between batches of brand-name products. Generic products are cheaper because manufacturers of exclusive brand-name medications pass on their cost of research, development, marketing and promotion. Once a medication is off-patent - or on the market about 17 years - a competing pharmaceutical company can copy the medication with comparatively little effort. Brand-name products do differ from generics in pill shape, color, taste and inactive ingredients.
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