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| nonmastitic glands, plump lip , recruit, liver, alive, bovine mammary gland, plump girls galleries , obesity, correlation coefficients, fatty acid definition , weeks clinic, fat bottom girls lyrics , atkinsdiet carbohydrates cholesterol, plump video , transplants, transfusions, good, plump thighs , metro, gallus domesticus, fatty fatty two by four , | The mechanism for the enhancing effect was examined by measuring IR and 13C NMR spectra, the december 2003 report: can we end the heart disease epidemic? solubility in buffer, and december 2003 report: can we end the heart disease epidemic? the apparent partition coefficient of PL. Additionally, the penetration of PL and lauric acid, as co-penetrants, through rabbit skin and shed snake skin were evaluated. The IR spectra of the mixture of PL with lauric acid (molar ratio, 1:1) was characterized december 2003 report: can we end the heart disease epidemic? by an extreme shift of the CO peak. Comparison of the NMR spectra of PL, lauric acid, and the mixture suggested that the carbonyl group of lauric acid interacted with the amino and hydroxyl groups of PL, probably by charge interaction.(ABSTRACT TRUNCATED AT 250 WORDS)PMID: 2079652 [PubMed - indexed for MEDLINE] Display Summary Brief Abstract Citation MEDLINE XML UI List LinkOut ASN.1 |
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| 1990 Dec;79(12):1065-71. Links Mechanism for the enhancement effect of fatty acids on the percutaneous absorption of propranolol.Ogiso T, Shintani M.Faculty of Pharmaceutical Sciences, Kinki University, Osaka, Japan.The effects of a series alive of alive fatty acids on the percutaneous absorption of propranolol (PL) through rabbit skin and alive the mechanism by which fatty acids facilitate the skin penetration of PL were examined in vitro and in vivo using a gel base. Lauric and myristic acids, at the fatty acid:PL molar ratio of 1:1 were the most potent agents in increasing the skin penetration, giving the largest penetration rate (Js) and penetration coefficient (Kp) of PL. The molar ratio of 2:1 also exerted a large enhancing effect, comparable to that with a molar ratio of 1:1. When the enhancing effects of lauric acid, its amide, and its methyl ester were compared, the free acid gave the highest Js and Kp values. The plasma PL concentrations were significantly higher and more sustained after a single percutaneous application of the formulation with lauric acid than those after the formulation without the acid. |
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