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Discrete inflammatory changes also largely disappeared and serum alkaline phosphatase was significantly reduced. Reduction in weight during this period ranged from 12% to 42%.27 In contrast, the weight loss induced by jejunoileal (J-I) bypass operations, in most cases, chronic seems to be accompanied by a chronic further increase in liver steatosis and fibrosis.28 Antibiotics After jejunoileal bypass, steatohepatitis has resolved with metronidazole therapy,29 but this treatment has chronic not been evaluated in primary NASH. Ursodeoxycholic Acid (UDCA) UDCA may have a membrane - stabilizing and cytoprotective effect. Treatment of NASH with UDCA for 12 months in a pilot study resulted in significant improvements in alkaline phosphatase, alanine transaminase (ALT), g-glutamyl transpeptidase (GGT) and hepatic steatosis, although there was no significant change in mean weight.30
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