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The effect of weight loss is variable; improvement occurs after gradual weight reduction,18 roferon although rapid weight loss may aggravate the histologic lesions of steatohepatitis.19 Pathogenesis: The pathogenesis of Nash is unknown. Accumulation of fat in the liver can occur because of: 1)increased delivery of free fatty acids roferon (FFA) to the liver; 2)increased synthesis of fatty acids in the liver; 3)decreased b-oxidation of FFA; and 4)decreased synthesis or secretion of very-low-density lipoprotein.20 Fatty liver without inflammation is a common histological finding encountered roferon in protein-energy malnutrition, obesity, acute starvation, carbohydrate overload, and corticosteroid therapy. Obese patients have greater stores of FFA in adipose tissue, are resistant to insulin, have normal or elevated levels of insulin and have higher plasma levels of (FFA).
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