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| military, ravenscourt park hospital, infection, bodybuilding, golden plump , editorial, exclusive, darshan kelley, fatty fuck , plump teens , liverdisease, plump dj's , heavy metals, exercise, plump grannies , | The most common finding at initial presentation is hepatomegaly,7-9 but splenomegaly, ascites and spider nevi are rare. Laboratory Features: The most frequently noted abnormality is a two-to threefold elevation of serum levels of ALT and AST.3,7-10 In the individual patient, the AST/ALT ratio will not discriminate alcoholic from non-alcoholic disease. Even if an AST/ALT ratio of greater than three is found significantly more often (p>0.001) in symptoms of fatty liver patients with alcoholic liver disease (82%), the ratio also exceeds symptoms of fatty liver three in 32% of nonalcoholics in one study.8 In another study,7 ratios of more symptoms of fatty liver than one are seen in 40% of nonalcoholics. Bilirubin levels are usually normal,3,6,8,9 and hyperbilirubinemia that barely exceeds 25 to 35 mmol/L is found in 12% to 17% of patients.8,9 |
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| Most patients are 10% to 40% heavier than ideal body weight and in one series, 49% of patients were more than 130% of ideal weight.9 Non-insulin-dependant diabetes mellitus is present in 25% to 75% of patients2,6-10 and it is a co-morbid factor with exercise obesity. In one series, only 8% of the patients were neither obese nor diabetic.8 The mean age at diagnosis exercise is 50 years, but ages range from 16 to 80 years.2,6-10 A high proportion of patients (48% to 100%) have no symptoms of exercise liver disease and a small percentage, especially children,11,12 have vague abdominal discomfort or pain in the right upper quadrant, and lethargy.9,10 Such patients present because of other conditions, (such as heart disease, hypertension, hypothyroidism, cholelithiasis, gynecologic or psychiatric conditions etc...) and are incidentally found to have abnormal liver function.8,9 Because of the associated conditions, these patients have frequently taken one or more medications.8,10 The diagnosis of primary NASH requires the exclusion of drugs which have been reported to produce secondary NASH, such as amiodarone, perhexilene maleate, synthetic estrogens, glucocorticoids and tamoxifen. |
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