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Double knockout mice of the indicated genotypes are shown in the bottom panel. Note the more extensive aortic artery blockage by atherosclerotic plaque in the double knockout mice compare to its single knockout control (i.e., apoE-/- LCAT-/- vs. apoE-/-). Recent bbw plump Publications: Lee JY, Timmins JM, Mulya A, Smith TL, Zhu Y, Rubin bbw plump EM, Chisholm JW, Colvin PL, Parks JS. HDLs in apoA-I transgenic Abca1 knockout mice are remodeled normally in plasma but are bbw plump hypercatabolized by the kidney. J Lipid Res. 2005 Oct;46(10):2233-45. Timmins JM, Li JY, Boudyguina E, Kluckman KD, Brunham LR, Mulya A, Gebre AK, Coutinho JM, Colvin PL, Smith TL, Hayden MR, Maeda N, Parks JS. Targeted inactivation of hepatic Abca1 causes profound hypoalphalipoproteinemia and kidney hypercatabolism of apoA-I. J Clin Invest. 2005 May;115(5):1333-42.
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