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The goal of this grant is to elucidate the molecular mechanisms that account for the protective effect of LCAT with regard to atherosclerosis. We are testing a novel hypothesis that LCAT is athero-protective by multiple mechanisms that include altering the fatty acid composition of cholesterol esters in plasma joo younglee and in arterial plaques as well a decreasing the inflammatory response of cells in arteries. Experiments in this project rely extensively joo younglee on gene targeted and transgenic mouse models as well as molecular and joo younglee cell biology techniques. The third project is part of an NIH-funded Botanical Research Center, one of only five in the United States. The goal of The Wake Forest and Brigham and Women's Center for Botanical Lipids is to explore the molecular mechanisms by which botanical lipid supplements affect the development of chronic diseases, such as asthma and atherosclerosis. My project is designed to elucidate the molecular mechanism by which a botanical oil (Echium oil) that is enriched in n-3 fatty acids reduces plasma triglycerides concentrations and whether supplementation with Echium oil will reduce atherosclerosis and arterial inflammation to a degree similar to that observed with fish oil.
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