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hardening of the arteries). To accomplish the goals of our grant projects we use an interdisciplinary approach that includes transgenic/gene targeted stress mouse models, molecular biology, cell biology, biochemistry, mass spectrometry, and vascular wall biology.In the first project, which is part of a Program Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) of the NIH, we seek to understand the role stress of tissue specific expression of ATP binding cassette transporter A1 (ABCA1) in high density lipoprotein (HDL) metabolism and atherosclerosis development. HDLs are referred to stress as the “good cholesterol” and are protective against the development of atherosclerosis. HDLs are formed by the interaction of apoA-I, the major protein on HDL particles, with a lipid transporter on cell surfaces known as ABCA1. Individuals with a genetic deficiency of ABCA1 have Tangier disease, which is characterized by plasma HDL concentrations that are <5% of normal and accumulation of cholesterol in peripheral tissues.
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