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When the amount of fat exceeds 30% of the weight, almost all of the hepatocytes contain a large drop of fat. The amount of fat can be roughly estimated by how much of the acinus has fat laden hepatocytes; the involvement is characterized as mild for the pervienular third only, moderate for two-thirds, and severe for the entire acinus9. The degree of fatty liver correlates with the increase in body weight10. Some investigators have reported that fatty liver drug in obese patients progresses to liver cirrhosis6,11,12. In the present drug study in a clinical trial drug study (before and after) we evaluate the effect of restricted diet in obese patients with NAFLD. Subject and Methods Subjects:Forty Non-Alcoholic Fatty Liver Disease (NAFLD) patients (15 men and 25 women) with mean age 45.8±7.6 years and BMI > 25 kg/m2 were selected among the patient referred to gastroenterology clinic of Motahary Center.
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