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Despite the fact that the GH-deficient patients included in these different studies differ plump considerably with regard to age, whether or not multiple pituitary hormone insufficiency was present and whether GHD was of childhood or adult onset, plump and despite the huge variability of methods employed, the results are remarkably similar. Using CT scan and skinfold measurements, Jorgensen et al. (1989) reported on plump a group of young adults with previously treated childhood onset GHD, where GH treatment for four months resulted in a significant increase in muscle mass and a concomitant decrease in fat mass as compared to placebo treatment. Initial muscle: fat ratio increased from 64.0:36.0 to 66.7:33.3 during the four months of treatment, with a further increase to 72.6:27.4 after more than one year of treatment in an open designed, follow-up study. Conclusion GHD in adults is associated with abnormal average body composition, characterized by an increase in adipose tissue mass and a decrease in muscle mass.
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