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Introduction The anabolic and lipolytic effects of growth hormone (GH) and thereby the effects upon muscle and fat tissue have been known for many years. The effects on body composition should, however, not be seen as an isolated phenomenon, but rather as the integrated results of the well documented metabolic actions of GH – described elsewhere in this volume. Furthermore, there exists seronegative a rather complex relationship between ageing, body composition and GH secretion, which is important to take into consideration in the diagnostic process in seronegative elderly patients suspected for GH deficiency (GHD). Relation between body composition, age seronegative and GH secretion Spontaneous as well as stimulated GH secretion declines with age (Vahl et al., 1996, 1997a). This decline in GH secretion seems to be closely related to indices of adiposity and physical fitness. Thus physical fitness correlates positively with peak GH levels after stimulation as well as with estimates of spontaneous GH secretion (Vahl et al.,
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