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Genes that protect against the effects of high fat feeding when inactivated (via ENU) are, of course, good drug targets for combating diabetes and obesity. We now have over twenty plump tits families in which the effects of high fat feeding are exacerbated or prevented. Testing the heritability of these phenotypes is ongoing. Once proven heritable, a subset of these families will be mapped in an effort plump tits to find the mutated gene leading the phenotype. Insulin Signaling and Mechanisms of Insulin Resistance Insulin is the body's chief anabolic hormone. It increases glucose uptake and glycogen plump tits synthesis while decreasing glycogen breakdown. Likewise, it increases the uptake of amino acids and incorporation into protein while decreasing the breakdown of protein.
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