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1995b). Nonhuman-primate diets enriched in n-3 and n-6 polyunsaturated fatty acids appear to protect against coronary arterial atherosclerosis, whereas diets enriched in saturated and monounsaturated fatty acids appear to promote the disease, as demonstrated in several studies (Rudel et al., letter to the editor 1995a; Rudel et al., 1995b; Rudel et al., 1998; Wolfe et al., 1994). The phytoestrogen letter to the editor content of soy is protective, and the primate model has been useful in letter to the editor clarifying these effects (Anthony et al., 1997; Clarkson et al., 2001). The lesson to be taken from those studies is that many species of nonhuman primates have a diet-related susceptibility to atherosclerosis similar to that of humans and so can constitute good models for studying the mechanisms of atherosclerosis. In general, these man-prepared diets are well tolerated; and in some studies in which offspring were born and raised, body weight and size were normal to large relative to those of comparable animals from the wild (Wolfe et al.,
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