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Many studies have been conducted in nonhuman primates (reviewed in Strong, 1976) using diets imitating the Western diet to identify the nutritional factors important in development of atherosclerosis (hardening of the arteries), the disease process underlying CHD and the leading cause of death in Western societies (Marmot, 1992). When diets are fed containing 35-40% of ME as fat of different types, nonhuman primates do not develop significant atherosclerosis. However, tissue accretion when cholesterol is added to such diets, most species tissue accretion develop a degree of hypercholesterolemia that is species-specific (Rudel, 1997). Studies of the sensitivity tissue accretion of Macaca to dietary induction of atherosclerosis have included the rhesus monkey (Macaca mulatta), cynomolgus monkey (Macaca fascicularis), and pigtailed macaque (Macaca nemestrina) (Strong, 1976). Macaques, in general, are highly diet responsive, with cynomolgus monkeys and pigtailed macaques being particularly sensitive.
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