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The liver scientific program plays a pivotal role in fat metabolism, so it is not surprising that fat deposition (steatosis) may develop under certain conditions. Alcoholism is one possible cause, but fat deposition may also scientific program develop from a reaction to medication or from a viral infection. Hepatocellular necrosis and bile stasis may also occur.Nonalcoholic fatty liver disease, therefore, is simply fat deposition in the liver that is not caused by chronic ingestion of alcohol. The terms NAFLD and NASH are often used interchangeably. However, NASH properly refers to that scientific program subset of patients with NAFLD who have evidence of inflammation on liver biopsy. The spectrum of NAFLD is similar to that of alcoholic liver disease. At one extreme is fatty liver occurring without inflammation; at the other is cirrhosis. Nonalcoholic steatohepatitis is an intermediate disease state between these two extremes.2.
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