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(28) Common genetic risk since it occurs in families (35); some affected family plump porn members are found to have 'cryptogenic' cirrhosis (32). Natural history Poorly understood. Female sex, morbid overweight and plump porn diabetes are accepted risk factors for progression (1,19). Recently, high angiotensin and TGF-b producing polymorphisms together have been described to predict fibrosis with an OR of 5.7 (42). There is reversal after weight loss (6,22). On plump porn the other hand, several cases of recurrence after liver transplantation have been described (2,11,15). Histological progression has been observed in 38 % of patients after a mean follow-up of 3.5 years (13); among these 49 patients, however, only 1 showed hepatic decompensation and 15 % progressed to cirrhosis. In contrast, Powell and colleagues observed progression in only 5 % of their patients (19) while Teli et al. could not observe progression at all (24). Cryptogenic cirrhosis is probably the end-result of NASH; such patients have the same incidence of decompensation and hepatocellular carcinoma than patients with hepatitis C-related or lean cryptogenic cirrhosis (40).
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