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by National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) December 2005 Sponsored by: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) Information copegasus provided by: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) copegasus ClinicalTrials.gov Identifier: NCT00262964 Purpose The primary goal of this study is to provide a better understanding of: 1) the pathogenesis and pathophysiology of non-alcoholic fatty liver disease (NAFLD) in obese subjects, and 2) the effect of marked weight loss copegasus on the histologic and metabolic abnormalities associated with NAFLD. The following hypotheses will be tested: obesity causes hepatic fat accumulation because of excessive fatty acid release from fat tissue and increased free fatty acid availability, increased hepatic (liver) fat content causes insulin-resistant glucose (sugar) production by the liver and altered liver protein synthesis, increased hepatic fat content causes increased lipid (fat) peroxidation, hepatic inflammation, necrosis and fibrosis, and marked weight loss improves NAFLD once patients are weight stable.
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