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If fatty liver of pregnancy steatohepatitis is present but a history of alcohol use is not, the condition is termed nonalcoholic steatohepatitis (NASH). Fatty change in the liver fatty liver of pregnancy results from excessive accumulation of lipids within hepatocytes. Simple fatty liver is believed to be benign, but NASH can progress to cirrhosis and can be associated with hepatocellular carcinoma. These changes are recognized on liver biopsy specimens, and, thus, the diagnoses are morphological rather than clinical.Pathophysiology: Fatty liver is the accumulation of triglycerides and other fats in liver cells. In some patients, this may be accompanied by hepatic inflammation fatty liver of pregnancy and liver cell death (steatohepatitis). Potential pathophysiological mechanisms include (1) decreased mitochondrial fatty acid beta-oxidation, (2) increased endogenous fatty acid synthesis or enhanced delivery of fatty acids to the liver, and (3) deficient incorporation or export of triglycerides as very-low density lipoprotein.Frequency:
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