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probable diagnosis in this group of patients is NAFLD. Whether a biopsy is acute fatty liver of pregnancy necessary to confirm the diagnosis should be decided after discussing its risks and the possible prognostic and therapeutic benefits. Because NAFLD is a benign condition in most patients, it is acute fatty liver of pregnancy prudent to reserve biopsy only for those who are most likely to have fibrosis. A recent study has suggested that old age, obesity, and diabetes mellitus increase the chance of fibrosis being found on examination of liver biopsy specimens.11. Are potentially hepatotoxic acute fatty liver of pregnancy medications contraindicated for patients who are thought to have NAFLD?Although there is no evidence that the incidence of drug-induced liver damage is increased among patients with NAFLD, liver enzyme levels should always be monitored carefully in any patient with presumed fatty liver who is receiving a drug with the potential for hepatotoxic effects.
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