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One can speculate that tissue uptake of n3 EFAs is impaired in this patient, producing the high levels of circulating n3s and the clinical response to n3 supplementation. This untreated n3 dependency allowed exacerbation of her symptoms in response to n6 EFAs; article its treatment permitted her to take n6 supplements without toxicity. General Comments These cases suggest that in some individuals dietary supplementation with relatively small doses of EFAs can produce striking clinical responses. Pronounced physiologic or pharmacologic effects of article dietary EFA supplementation have been demonstrated in controlled studies of LA supplementation in diabetic angiopathy [69] and hypertension article [70]; clinically significant immunosuppression has been obtained from 3 gm per day of EPO [71], and marked changes in platelet function have appeared after prolonged ingestion of small doses of LNA [72].
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